Penetration of 14C-methisoprinol into rabbit eyes with experimentally induced herpetic keratitis

Penetration of 14C-methisoprinol into rabbit eyes with experimentally induced herpetic keratitis

Academic Journal
(English) By: Alberghina M; Tognon M; Cassai E; Gorgone G; Cavallaro N; Filippello M; Scaletta S,

Ophthalmologica. Journal International D’ophtalmologie. International Journal Of Ophthalmology. Zeitschrift Für Augenheilkunde [Ophthalmologica]

ISSN: 0030-3755, 1986; Vol. 192 (1), pp. 46-8; Publisher: Karger; PMID: 2422617;

The authors studied the penetration of 14C-labelled methisoprinol into ocular tissues (cornea, aqueous humour and iris) in rabbits, in which herpetic keratitis had been experimentally induced. It has been demonstrated that the methisoprinol crosses the corneal barrier. The maximum concentration of the drug in the tissues examined was measured 30 min after the instillation of the drug into the conjunctival sac, and persisted for 60 min, although at a slightly lower level.

Subjects: Eye metabolism; Inosine analogs & derivatives; Inosine Pranobex metabolism; Keratitis, Dendritic metabolism; Female

 

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A cura del Dr. Massimo Filippello

Centro oculistico a Catania

Il Dott. Massimo Filippello è specializzato in blefaroplastica e tossina botulinica, cross linking accelerato corneale e transepiteliale, cheratocono, terapia degenerazione maculare e presbiopia, operazione miopia laser.

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